THE FUTURE OF INJECTABLE COLLAGEN
KARISMA Rh Collagen is the world’s first pure injectable Recombinant Human Collagen Type 1. This Class III, re-absorbable medical device restores pre-aging skin conditions by rejuvenating the extracellular matrix and stimulating natural collagen production for long-lasting results.
R polypeptides α1 chain of type I collagen
High Molecular Weight Hyaluronic Acid
Carboxymethyl
Cellulose
WHY Karisma Rh Collagen?
It’s a multi-functional “bio-stimulatory soft filler” combining: Collagen boost : Recombinant human collagen Polypeptidic α1 Chain ( Rh Collagen ) Hydration : High Molecular Weight Hyaluronic Acid ( HMW - HA / 400 mg ) Stability to preserve effectiveness : Carboxymethylcellulose ( CMC ) This synergy leads to younger-looking, thicker, and firmer skin due to increased collagenconcentration.
Has a very low risk of allergic reactions (99,9% of similarity)
Has 100% solubility with a dimension of 100 kDa
Due to its mono-filament it is immediately bioavailable.
KARISMA Rh Collagen®
Increases the production of procollagen type I C-Peptide in fibroblasts. The R polypeptides α1 chain of type I collagen contained in KARISMA FACE Rh Collagen® (a new patented technology) is synthesized by transgenic silkworm and secreted in their cocoon. Hydroxylated α1 chain of recombinant type I collagen acts as a precursor in the synthesis of endogenous collagen.
Enhance Your Own Collagen Production
Enhance Your Own Collagen Production
• Contains a recombinant human collagen 1 α1 polypeptide that encourages fibroblasts
to produce type I collagen, improving skin density and firmness.
Provides Deep Hydration & Instant Plumping
Provides Deep Hydration & Instant Plumping
• High molecular weight hyaluronic acid boosts skin hydration, adds immediate volume,
and supports collagen synthesis
• Carboxymethyl cellulose (CMC) helps retain hyaluronic acid by slowing its degradation,
prolonging hydration duration
Improves Skin Quality & Texture
Improves Skin Quality & Texture
• Regular treatments flatten fine lines, smooth skin texture, and diminish light acne scars
or stretch marks.
• Clinical assessments at 30 days post treatment show visible improvement in
skin regeneration and aesthetics
Delivers Gentle, Safe, Long Lasting Results
Delivers Gentle, Safe, Long Lasting Results
• Karisma Collagen is 99.9% identical to the natural collagen found in human skin,
making it highly compatible and free from allergy risks
• Effects can last 18– 12 months, depending on adherence to the treatment protocol
and individual lifestyle factors
KARISMA Rh Collagen
Increases the production of procollagen type I C-Peptide in fibroblasts. contained in KARISMA FACE Rh Collagen (a new patented technology) Hydroxylated α1 chain of recombinant type I collagen acts as a precursor in the synthesis of endogenous collagen.
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Effect of Karisma Rh Collagen on cell Viability and growth rate
Effect of Karisma Rh Collagen on intracellular collagen I levels in normal and aged HDFs
Effect of KARISMA Rh Collagen® on intracellular collagen I levels in normal and aged HDFs
Effect of KARISMA Rh Collagen® on aging of HDF induced by H2O2
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THE FUTURE OF INJECTABLE COLLAGEN
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